主要承担项目及成果 | 1. 承担项目 主持国家自然科学青年基金1项，陕西省自然科学青年基金1项,中国博士后面上项目西部资助1项，陕西省中医药管理局研究项目1项，英国威廉希尔公司官网人才科研启动项目1项，；参与国家自然基金面上及重大专项等项目多项，部分主持项目如下： [1]国家自然科学基金：雷公藤甲素通过miR-125b-5p下调雌激素受体α抗乳腺癌增殖的分子机制研究，20万 [2] 秦创原中医药创新研发转化项目：古代名方三化汤开发研究, 8万元 [3] 中国博士后面上项目：金纳米棒修饰的去氢骆驼蓬碱脂质体的制备及抗肝癌作用，8万 [4] 陕西省自然科学基金青年项目：雷公藤甲素选择性抑制雌激素受体阳性乳腺癌增殖的分子机制研究，3万 2. 论文/论著 发表SCI学术论文十余篇，获批专利十余项，参编写著作1部。部分代表性论文如下： [1] Li, Han, et al. Effects of triptolide on the sphingosine kinase -Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer, International Immunopharmacology, 2020, 88: 0-106892 [2] Li, Han, et al. Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease, European Journal of Medicinal Chemistry, 2020, 192: 112163 [3] Li, Han, et al. Antitumor properties of triptolide: phenotype regulation of macrophage differentiation, Cancer Biology & Therapy, 2019, 21(2): 178-188 (期刊论文) Li, Han, et al. [4] Li, Han, et al. "Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERα-mediated signaling pathway." Acta Pharmacologica Sinica 36.5 (2015): 606-613. 3. 专利 [1]Li, Han, et al. DIHYDROXYTYROSOL HEXAMETHYLENE-1,6-DICARBAMATE HAVING ANTIOXIDANT ACTIVITY AND A METHOD OF PREPARING THE SAME, 2019-7-13, 美国, 16/510, 906 [2]Li, Han, et al. 1-OACETYLBRITANNILATONE SPIRO ARYL ISOXAZOLINE COMPOUNDS, 2018-10-23, 美国, 16/167, 598 [3]Li, Han, et al. 6-AMINOURACIL CASSIC ACID ESTER WITH ANTIBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME, 2020-6-23, 美国, 16/909, 862 [4]Li, Han, et al. CINNAMYL ALCOHOL CASSIC ACID ESTER WITH ANTTBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME, 2020-6-27, 美国, 16/914, 326 |
